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In conclusion, these results argue against the value of augmented generic immunosuppression beyond steroids for frontline treatment of aGVHD and emphasize the importance of developing alternative strategies. Novel forms of immunomodulation and targeted therapies against non-immune-related pathways may enhance the efficacy of steroids in this setting, and early predictive and prognostic biomarkers can help identify the subgroup of patients who would likely need treatments other than or in addition to.
Prostate cancer PCa is a leading cause of death in men worldwide. The main reason for the progression of prostate cancer is identified as over activation of androgen receptor AR through androgens.
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Its development can be diagnosed by monitoring the prostate specific antigen PSA. Treatment of PCa includes prostatectomy, radiotherapy, and chemotherapy, among them chemotherapy is normally employed in early and advanced prostate cancer. Chemotherapy mainly includes two classes of drugs which are steroidal and non- steroidal antiandrogens.
The non- steroidal classes of compounds are preferred over steroidal because they are relatively safe, cost effective and diverse. Non- steroidal drugs are commonly used for the treatment of PCa, however these drugs are associated with serious side effects and acquired resistance.
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So researchers are working in the direction to develop better analogue which can address the issue related to resistant type of prostate cancer. This review discusses the advancement in the non- steroidal antiandrogens which offers a better potential in the treatment of prostate cancer. Opening a door to safe abortion: international perspectives on medical abortifacient use. International experience compels us to revisit how we define and assess the safety and efficacy of medical abortifacients such as misoprostol.
In some countries where safe abortion is neither accessible nor legal, even unsupervised, off-protocol use of misoprostol can provide women with a means to safely terminate pregnancy. This is due primarily to misoprostol-induced uterine contractions that cause bleeding, which in turn provides access to existing reasonable quality health services that would otherwise be unavailable. Several studies have suggested that an increase in the underground use of misoprostol in Brazil has already reduced serious complications from unsafe abortion.
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